Skip to content

Does Cannabis Have Any Drug Interactions?

cannabis leaf

Marijuana or marihuana, known as cannabis sativa, can be an effective treatment for a number of health conditions. However, the drug itself can often cause problems in those who want to use it for medical purposes, due to the number of physical and psychological side effects.

Cannabis does have some drug interactions, however, the chemical interactions are not as bad as you would think. Although some people may experience some minor drug interactions.

Many people believe that cannabis use is completely safe, but all drugs, including cannabis, are potentially harmful. That’s why it’s important to ensure that you’re using your drugs responsibly, and not taking more than recommended, to avoid any adverse effects.

Smoking cannabis can cause users to feel dizzy, lightheaded, or even faint. This is especially true for users who have a low tolerance level for cannabis.

Combining cannabis with alcohol can intensify and prolong the effects. Propylene Glycol, also referred to as PG, is an organic compound that is widely used as a liquid medium in which to dissolve flavorings and active ingredients for e-juice.

How do you defined drugs?

To me, drugs are a substance that alters your mental state. A drug that gives you a physical high is not a drug.

The subject of drugs is one that most people do not take lightly. Those who take drugs, are likely ones who are facing some form of substance abuse problem. Many of them are likely using the drugs to avoid the problems they are facing.

How does cannabis interact with other drugs?

A question that arises frequently in the online cannabis community is “How does cannabis interact with other drugs?”

It’s a good question because there are many different drugs out there, each with their own effects on the body. Some drugs, like alcohol, can be substituted for cannabis with little to no effect.

Other drugs have a much more noticeable effect on the body’s response when mixed with cannabis.

For example, certain drugs like ephedrine and caffeine are known to induce a high while cannabis can be considered to promote a “munchies” effect when used in tandem.

Cannabis is a mix of chemicals that includes THC, the part that affects the brain and other parts of the body. When the body processes THC, it can affect the way other chemicals that are also in the body work. 

Some of the drugs that may interact with cannabis include:

  • Alfentanil

Alfentanil is a very strong opioid analgesic used to treat moderate to severe pain. It has a high ceiling and a very fast onset of action, but only lasts a short period of time.

This makes it a powerful drug that is not suitable for long-term use. Since Alfentanil may be broken down in the human body, it is important to know what drugs it may interact with.

  • Ambien

Ambien is a popular drug in the United States, prescribed to millions of people to help them sleep. As a sleeping pill, it is commonly used by people suffering from insomnia, but has also been associated with approximately 500,000 emergency-room admissions every year.

Ambien is generally safe when taken as directed, but it is not without risk. Ambien interacts with cannabis, and users of cannabis should not take it.

  • Amphetamines

Amphetamines is an example of a drug that may interact with cannabis. The effects of cannabis and amphetamines are very similar.

Their effects include stimulation, euphoria, euphoria, altered perception of time, and a feeling of increased energy. Many people combine the use of amphetamines with cannabis for this reason, but this combination can be dangerous.

Amphetamines are a class of psychostimulant drugs that are usually used to treat attention deficit hyperactivity disorder. Amphetamines are used by people with ADHD to improve attention span, concentration and focus.

  • Armodafinil

Armodafinil is a smart drug, like Adderall, that is known to be an effective stimulant. As with all drugs, Armodafinil can interact with other substances.

The problem with cannabis is that it is a substance that can be both a stimulant and a depressant. A smart drug like Armodafinil can make the effects of cannabis seem to temporarily disappear.

Unfortunately, this can lead some people to believe that the drug is working when it is not.

Armodafinil is a very potent stimulant that’s been used to treat narcolepsy and other sleep disorders. It’s so potent that doses of 100mg or above can cause excitement and anxiety.

Armodafinil is used to treat patients with depression and exhaustion disorders.

  • Aspirin

Aspirin is a well known pain reliever. It has been used for around 150 years to reduce pain in various parts of the body. It is also a very effective anti-clotting agent.

It can be used as a non-steroidal anti-inflammatory drug (NSAID), a blood thinner, an anti-platelet agent (aspirin) and an anti-coagulant.

Now that cannabis has been legalized in some US states, some people are concerned about the potential for aspirin to interact with the drug.

Aspirin is an example of a drug that may interact with cannabis. Aspirin and other NSAIDs and COX-2 inhibitors are associated with an increased risk of bleeding in people that use marijuana.

This risk is generally thought to be due to the way in which NSAIDs work in the body.

  • Barbiturates

Barbiturates is an example of a drug that may interact with cannabis. Barbiturates are a class of medication that are depressants, just like alcohol.

This means they take the body’s natural ability to manage natural processes such as breathing, heart rate, and the autonomic nervous system and inhibit or slow them, causing increased stress in the body and a higher level of anxiety.

  • Buprenorphine

Buprenorphine is an opioid medication and the most commonly used form of opioid pain medication prescribed by doctors. It is an extended-release formulation of the drug known as thebaine, which is derived from the opium poppy.

It is a long-acting opioid, which means that it is released from the body slowly and longer durations of use are needed to cause the desired effect.

  • Butorphanol

Butorphanol is an example of a drug that may interact with cannabis. Butorphanol is sometimes used to treat pain or discomfort of opioid induced side effects.

Other names for this drug include: Butalbital, U-47700, Nalbuphine, Nubain, and Naloxone.

It has been found in cannabis by some, but not all, studies done to date. However, when it has been found in cannabis, it has been found to interact with the compounds found in cannabis, and has been shown to have a negative effect on the users.

  • Buspirone

Buspirone is a drug that is used by some people to treat anxiety, insomnia and depression. It is also known as BuSpar, and is manufactured by Bayer.

It is an antipsychotic medication, and is sometimes used to treat symptoms of Alzheimer’s disease. It works by blocking the action of a neurotransmitter called serotonin, and is used to treat anxiety disorders, insomnia, some types of depression and to treat agitation in people with dementia.

Buspirone has also been shown to improve the symptoms of sleep disorders in people with Parkinson’s disease and to alleviate the symptoms of some types of pain.

  • Clonazepam

Clonazepam, more commonly known by its trade name Klonopin, is a medication that is prescribed for the treatment of anxiety and seizure disorders.

It is primarily used to treat panic attacks and seizures, but its side effects are common to other benzodiazepine drugs, including addiction and dependence.

  • Codeine

The term codeine has become a somewhat common term among marijuana users, because it is a highly-addictive opiate that is used to treat pain. The active ingredient in codeine is morphine, which allows the drug to act on the central nervous system and alleviate pain.

Unfortunately, the effects of this drug can be extremely dangerous, and it’s highly addictive. Codeine can build up in the body and cause serious problems, such as an increased risk of kidney disease.

  • Colchicine

Colchicine is a drug used for the treatment of gout. In medicine, it is used to treat gout when other medicines such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and corticosteroids fail to relieve symptoms.

Colchicine works by inhibiting the breakdown of uric acid in the body. Uric acid is a natural component of the body, which is necessary for healthy functioning, and drug treatment of gout aims to reduce the amount of uric acid that is present in the body.

The use of colchicine for gout is not without risk, so it is important to be aware of potential side effects when taking this medication. It is not recommended to use colchicine in conjunction with cannabis.

  • Dihydrocodeine

Dihydrocodeine is one of the most potent opiate pain relievers, but it is potentially dangerous for users who are also regular cannabis users.

Dihydrocodeine is a central nervous system depressant, and the exact mechanisms by which it affects the endocannabinoid system are not fully understood. The drug has similar effects to morphine, and is used to treat severe pain and severe diarrhea.

  • Diltiazem

Diltiazem is a drug that is used to treat high blood pressure, heart failure and angina. It is a calcium channel blocker.

The drug is also used to help stop the progression of seizures in people who are in the early stages of their development. It is also used to treat chronic pain.

Most people would think that diltiazem is not a drug that would interact with THC, but a recent study shows that it can. Diltiazem is a commonly prescribed drug that is in many heart medications.

It is a non-selective adrenergic blocker that also acts as a calcium channel blocker.

  • Doxylamine

Doxylamine is an example of a drug that may interact with cannabis. Doxylamine is a sedative used for the treatment of insomnia and anxiety disorders.

It can be taken orally as a tablet or in pill form, or it can be injected or swallowed in liquid form. It is also an ingredient in many cough syrups. It is considered to be a phenyltoloxamine derivative.

  • Efavirenz

Efavirenz is an antiretroviral medication first developed in the 1980s. It is typically prescribed to HIV positive patients to help control the viral load of the virus.

In 2007, it was found that efavirenz was associated with a cannabis dependence syndrome in patients that had previously been prescribed the medication.

The syndrome is characterized by an increasingly frequent cannabis use, and other cannabis-related behaviors (such as working in cannabis related industries, or living at cannabis related addresses) in patients who were previously considered to be stable.

  • Ephedrine

Ephedrine is an alkaloid extract found in many plants. One of the most notable is the Ephedra plant, which is native to the arid parts of Asia and is sometimes referred to as Ma Huang.

Ephedrine is also found in other plants, such as the American Ephedra (also known as Ma Huang) and the Ephedra sinica (Ephedra equisetina, Ephedra sinica, or Ma Huang).

The plant’s parts are used for their stimulant properties, but the plant’s root is the main active ingredient. Although ephedrine is often found as a component of over-the-counter cold remedies, it is very rarely used alone.

For some people, cannabis and ephedrine (and other similar substances) can cause serious medical complications that can lead to death.

  • Fenfluramine

Fenfluramine, also known as Redux, is a drug that may interact with cannabis. Commonly used to treat obesity and maintain steady blood sugar levels, it is also found in some diet pills.

The same chemical that makes phentermine work in the body may also interact with the CB1 receptors within the brain to produce a euphoric effect.

This may explain the increased appetite, weight-gain, and sensitivity to insulin that are reported by some users of both phentermine and cannabis.

  • Fluvoxamine

Fluvoxamine is an antidepressant that may interact with cannabis (marijuana) and other drugs. Fluoxetine is the active ingredient in the prescription drug Luvox , which is marketed as an anti-anxiety and anti-depressant drug.

Fluoxetine has a half life of 10–11 hours and accumulates in the fat tissue of the body.

  • Flecainide

Flecainide is an example of a drug that may interact with cannabis. Flecainide, a potent anti-arrhythmic, is a Class B drug under the Misuse of Drugs Act, and it is no longer available to be purchased in the UK.

Before it was withdrawn, it was used to treat a number of conditions, including atrial fibrillation, and was in fact the drug of first choice for this condition.

Flecainide has a good safety record, but because of its potency, it can cause some very serious side effects, including seizures and cerebral hemorrhage. There is also a theoretical risk of interaction with cannabis.


Ryan Hamilton

Im Ryan, a Medical Cannabis Activist & Blog Owner @ I started the blog as a medium to answer questions and grow the awareness of the herb. Along with the medicinal properties, cannabis can help grown the economy with its vast amount of taxable finances. Less violent properties than alcohol, cannabis legalisation is inevitable.

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.